The influence of rs139416141 in neighbor of Brca1 gene (NBR1) on bone mineral density in postmenopausal Chinese women

• 作者: Haojie Wu Jianming Hou Lijie Zhao Yang Zhang Ying Xue Zhenlin Zhang Zinan Zhang
• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: New Phenomenon
• 页码范围: 1047-1049
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmaa070

摘要

Bone mineral density (BMD) is used to assess bone mass at present and ～70％ of the variance is determined by genetic factors [1].BMD in a lifetime is in a dynamic change from peak values obtained during growth to a gradual decrease during postmenopause and aging.Bone micro-architecture deterioration in postmenopausal women is a result of increased bone remodeling and liable to fracture of the hip, wrist and spine [2].This bone remodeling imbalance due to estrogen deficiency causes skeletal tissues in the state of enhancement of osteoclastogenesis and impairment of osteogenesis.