ARG1 functions as a tumor suppressor in breast cancer

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2020,（11）
• 所属期刊栏目: Original Articles
• 页码范围: 1257-1264
• 页数: 8页
• 语种: 英文

摘要

Arginase Ⅰ(ARG1)is a cytosolic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea.The association of ARG1 with cancer has mostly been focused on the ARG1 released by tumor-associated myeloid cells in tumor microenvironment.However,the role of ARG1 expressed in cancer cells is unclear.Here,we showed that the expression of ARG1 in human breast can-cer(BC)is related to a good prognosis in BC patients.Overexpression of ARG1 suppresses BC cell proliferation and migration in vitro and xenograft tumor growth and development in mouse models.Furthermore,ARG1 expression down-regulates the expression of p-AKT,leading to the de-activation of AKT signal pathway in BC cells.Thus,our results established that in contrast to the role of ARG1 released from tumor-associated myeloid cells in tumor microenvironment that promotes tumor immune escape,ARG1 expressed in BC cells suppresses AKT signaling pathway and functions as a tumor suppressor.