Recently,high-and medium-entropy alloys (HEAs and MEAs) have been found to exhibit excellent cryo-genic mechanical properties,but most of them contain high-priced Co element.Therefore,developing HEAs or MEAs with high strength and ductility and relatively low cost is urgent.In this work,novel Co-free FexMn75-xNi10Cr15 (x =50 and 55 at.%) MEAs were developed,which exhibit a good combination of low cost,high strength and ductility at cryogenic temperature.It was found that the Fe50Mn25Ni10Cr15 MEA exhibits a combination of cryogenic tensile strength of ~ 0.98 GPa and ductility of ~ 83 %.The excel-lent cryogenic mechanical properties were attributed to joint of twinning-induced plasticity (TWIP) and transformation-induced plasticity (TRIP) effects.The present study sheds light on developing low cost MEAs with high performance for cryogenic-temperature applications.