Murder on the Orient Express, a masterpiece in the detective fictions, is one of the most prevailing works of Agatha Christie. It provides special modes and new ideas for the later creation of the detective stories. Suspense is embodied largely in this book. A variety of suspense interweaves, overlaps and creates the stirring effect. This thesis first introduces the lifetime of the au?thor, the typicality of the book among the same kind of detective fictions. Then it aims at explaining and analyzing the suspense set?tings from the narrative time, the narrative point of view, clues in the book and the ending of the story by using the text analysis. Fi?nally, it states the significance of suspense settings. The study of suspense settings can not only dissect the artistic value and the charm of suspense in detective fictions but also contribute to improving readers'abilities of appreciating mystery stories. It can help them to shape a unique aesthetic perspective.