Vitamin D and Its Association with Glycemic Status in Bangladeshi Adults with Newly Detected Type 2 Diabetes Mellitus

• 作者: Md. Firoj Hossain Tahniyah Haq Md. Fariduddin Shahjada Selim M. A. Hasanat Md. Shahed-Morshed
• 来源期刊: 内分泌与新陈代谢疾病期刊(英文)
• 学科: 医学
• 关键词: Vitamin D Type 2 Diabetes Mellitus Vitamin D Deficiency Glycated Hemoglobin A₁c
• 年，卷（期）: 2021,（1）
• 页码范围: 1-11
• 页数: 11页
• 分类号: R58

摘要

<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong><em>Background:</em></strong> Very limited data are available regarding the association of vitamin D with glycemic status among adults with newly detected type 2 diabetes mellitus (T2DM) in Bangladesh. <strong><em>Objectives:</em></strong> To determine vitamin D status and its association with glycemic status in Bangladeshi adults with newly detected T2DM. <strong><em>Materials and Methods:</em></strong> This cross-sectional study was carried out in 102 newly detected T2DM diagnosed on the basis of the American Diabetes Association 2017 criteria (age: 42.95 ± 10.68 yrs.;m/f: 44/58) and equal number of age and sex matched controls (age: 40.43 ± 11.04 years) recruited consecutively from the Department of Endocrinology, BSMMU to measure serum vitamin D by high performance liquid chromatography method. <strong><em>Results:</em></strong> Both vitamin D deficiency (<20 ng/ml) (87.3% vs. 74.5%, <em>p </em>< 0.03) and severe vitamin D deficiency (<10 ng/ml) (56.2% vs. 26.3%, <em>p</em> < 0.001) were significantly higher in people with T2DM than control population. The mean level of 25(OH)D was significantly lower in adults with T2DM than control population (12.41 ± 6.85 ng/ml vs. 15.74 ± 6.25 ng/ml, <em>p</em> < 0.001). A significant inverse correlation was observed between vitamin D & HbA<span style="white-space:nowrap;">₁</span>c (r = <span style="white-space:nowrap;">&#45;</span>0.249, <em>p</em> = 0.011) in patients with T2DM. HbA<span style="white-space:nowrap;">₁</span>c was linearly associated with vitamin D (<em>β </em>= <span style="white-space:nowrap;">&#45;</span>0.26, <em>p</em> = 0.009) and severe vitamin D deficiency by binary (OR = 1.37, <em>p</em> = 0.003) and multinomial logistic regression (HbA<span style="white-space:nowrap;">₁</span>c ≥ 10%: OR = 4.25, <em>p </em>= 0.04) in people with T2DM after adjustment for age and BMI. <strong>Conclusions:</strong> Severe vitamin D deficiency was p