Editorial commentary on the special issue of CRISPR Trends in Biomedical Research

• 作者: Hongbing Shen
• 来源期刊: 生物医学研究杂志（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: EDITORIAL COMMENTARY
• 页码范围: 75
• 页数: 1页
• 语种: 英文

摘要

In 2012, the laboratories of Drs.Emmanuelle Charpentier and Jennifer Doudna reported the repurposing of a bacterial adaptive immune system, known as CRISPR, as a programmable, RNA guided DNA editing system in eukaryotic cells.Over the next 12 months, a tsunami of research papers emerged demonstrating the facile utilization of this newfound genome editing platform in a variety of cell types and animal models.Since 2013, we have witnessed "global CRISPRization" with applications ranging from preservation of key crops and gene drives for the potential control of insect-borne diseases such as malaria and dengue to somatic genome editing with scores of clinical trials underway.From an experimental perspective, CRISPR has revolutionized and democratized the development of novel animal models across species and provided key insights into new gene therapies for a variety of hereditarydiseases.