Prevalence, Species Distribution and Antifungal Susceptibility Profile of <i>Candida</i>Species Isolated from Bloodstream of Critical Care Unit Patients in a Tertiary Care Hospital in Kenya

• 作者: Danait Andemichael Solomon Andrew K. Nyerere Alice Kanyua Caroline Wangari Ngugi
• 来源期刊: 医学微生物学(英文)
• 学科: 数学
• 关键词: Critical Care Unit Candida Species Candida auris CANDIDEMIA Antifungal Susceptibility
• 年，卷（期）: 2021,（1）
• 页码范围: 32-46
• 页数: 15页
• 分类号: O17

摘要

<span style="font-family:Verdana;">The </span><span style="font-family:""><span style="font-family:Verdana;">upsurge of candidemia in the past years has been an immense encumbrance on public health and the number of deaths caused by candidemia particularly in critical care unit patients is devastating. </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> species harbor a 30</span></span><span style="font-family:Verdana;">% </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">60% mortality rate and compared to stable people or those with less serious illnesses, this ranges from 60</span><span style="font-family:Verdana;">%</span><span style="font-family:Verdana;"> to 80% of those who are chronically ill patients. Grounded on a recent report from a tertiary care hospital in Kenya showing the emergence of previously unobserved species</span><span style="font-family:Verdana;">:</span><span style="font-family:""> <i><span style="font-family:Verdana;">Candida auris</span></i><span style="font-family:Verdana;">, this study aimed to determine the prevalence, species distribution, and antifungal susceptibility profile of candidemia in critical care unit patients of the hospital. 378 Critical Care Unit patients were enrolled for the study from January 2019 to January 2020. Positive archived isolates were sub-cultured using Sa</span><span><span style="font-family:Verdana;">boraud Dextrose Agar. </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> species were identified utilizing API20C</span></span><span style="font-family:Verdana;"> AUX and Vitek-2. Antifungal susceptibility testing was conducted using the Liofilchem MIC Test strip. Out of 378 patients, thirty-one presented a positive culture for </span><i><span style="font-family:Verdana;">Candida</span></i><span style="font-family:Verdana;"> species. The prevalence of Candidemia was </span><b><span style="font-fa