Selenium’s Utility in Mercury Toxicity: A Mini-Review

• 作者: Roswell Timmerman Stanley T. Omaye
• 来源期刊: 食品与营养科学(英文)
• 学科: 数学
• 关键词: MERCURY SELENIUM TOXICITY SELENOPROTEINS Human Health Oxidative Stress
• 年，卷（期）: spyyykxyw,（2）
• 页码范围: 124-137
• 页数: 14页
• 分类号: O17

摘要

<b><span style="font-size:12px;font-family:Verdana;">Purpose: </span></b><span style="font-size:10.0pt;font-family:""><span style="font-family:Verdana;font-size:12px;">This review of the literature intends to provide readers an understanding of the prophylactic and antidotal usefulness of selenium (Se) for mercury (Hg) toxicity. We will provide an explanation of Hg and Se interactions for potential remediation options to contaminated ecosystems.</span><b><span style="font-family:Verdana;font-size:12px;"> Design/methodology/approach: </span></b><span style="font-family:Verdana;font-size:12px;">In this mini-review, we discuss mechanistic aspects between Hg and Se, the implication for health outcomes, and its usefulness in the ecological recovery of Hg contaminated areas. </span><b><span style="font-family:Verdana;font-size:12px;">Findings: </span></b><span style="font-family:Verdana;font-size:12px;">Mercury has a strong affinity for Se, resulting in Se-dependent enzymes and proteins’ deactivation with devastating consequences to the host. It is likely that Hg’s toxicity results in Se deficiency. Selenium compounds can have prophylactic or antidotal effects to prevent or reverse the adverse toxicity action of Hg exposure. Current research indicates that the chemical interactions between Hg and Se are unique. The Hg capturing capacity of Se is a million times higher than sulfur compounds and results in inactive complexes. </span><b><span style="font-family:Verdana;font-size:12px;">Practical implications: </span></b><span style="font-family:Verdana;font-size:12px;">Future work can target engineering methods for technologies that can reduce the toxicity of Hg in the environment.</span></span><span style="font-size:10.0pt;font-family:""> </span><b><span style="font-size:12px;font-family:Verdana;">Originality/value: </span></b><span style="font-size:12px;font-family:Verdana;">The unique interactions between the elements are that Hg can compromise Se dependent enzymes;however, pharmacologic doses of Se can prevent or