Myelodysplastic Syndrome Secondary to Multiple Myeloma: A Case Report and Literature Review

• 作者: Wanqiu Zhang Qianshan Tao Yinwei Li Yin Pan Qing Zhang Fan Wu Zhimin Zhai
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Multiple Myeloma Myelodysplastic Syndrome KARYOTYPE THALIDOMIDE
• 年，卷（期）: 2021,（3）
• 页码范围: 39-43
• 页数: 5页
• 分类号: R73

摘要

<strong>Background:</strong> With the prolongation of survival in recent years, the accumulation of toxic and side effects of therapeutic drugs and the concomitant drug-related adverse reactions were reported in recent years. However, myelodysplastic syndrome secondary to multiple myeloma is rare. <strong>Objective: </strong>To improve the understanding of myelodysplastic syndrome secondary to multiple myeloma. <strong>Methods: </strong>The clinical data of a patient with myelodysplastic syndrome secondary to multiple myeloma after treatment were analyzed, and the related literature was reviewed. <strong>Results: </strong>A 54-year-old male patient was diagnosed as multiple myeloma in February 2014. After three courses of first-line induction chemotherapy, he achieved complete remission and received two courses of consolidation treatment. After that, he continued to take thalidomide orally. The disease recurred 13 months after complete remission (CR) with 6q+ karyotype change in 37 months. 21q- karyotype change was found in 39 months. The patient was finally diagnosed as treatment-related secondary myelodysplastic syndrome. Due to the poor effect of chemotherapy, the disease continued to deteriorate. <strong>Conclusion: </strong>In the course of multiple drug treatment, clinicians should pay attention to the changes of molecular genetics and the treatment-related secondary tumor.