The dynamic changes of arsenic biotransformation and bioaccumulation in muscle of freshwater food fish crucian carp during chronic dietborne exposure

• 作者: Di Cui Peng Zhang Haipu Li Zhaoxue Zhang Yang Song Zhaoguang Yang
• 来源期刊: 环境科学学报（英文版）
• 年，卷（期）: 2021,（2）
• 页码范围: 74-81
• 页数: 8页
• 语种: 英文

摘要

Dietary uptake is the major way that inorganic arsenic(iAs)enters into benthic fish;how-ever,the metabolic process of dietborne iAs in fish muscle following chronic exposure re-mains unclear.This was a 40-day study on chronic dietborne iAs[arsenite(AsIII)and arse-nate(AsV)]exposure in the benthic freshwater food fish,the crucian carp(Carassius aura-tus),which determined the temporal profiles of iAs metabolism and toxicokinetics during exposure.We found that an adaptive response occurred in the fish body after iAs dietary exposure,which was associated with decreased As accumulation and increased As trans-formation into a non-toxic As form(arsenobetaine).The bioavailability of dietary AsIII was lower than that of AsV,probably because AsIII has a lower ability to pass through fish tis-sues.Dietary AsV exhibited a high potential for transformation into AsIII species,which then accumulated in fish muscle.The largely produced AsIII considered more toxic at the earlier stage of AsV exposure should attract sufficient attention to human exposure assess-ment.Therefore,the pristine As species and exposure duration had significant effects on As bioaccumulation and biotransformation in fish.The behavior determined for dietborne arsenic in food fish is crucial for not only arsenic ecotoxicology but also food safety.