Lipids and membrane-associated proteins in autophagy

• 作者: Linsen Li Mindan Tong Yuhui Fu Fang Chen Shen Zhang Hanmo Chen Xi Ma Defa Li Xiaoxia Liu Qing Zhong
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: REVIEW
• 页码范围: 520-544
• 页数: 25页
• 语种: 英文

摘要

Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has been linked to various diseases.Autophagy is a membrane driven process and tightly regulated by membrane-associated proteins.Here,we summarized membrane lipid compo-sition,and membrane-associated proteins relevant to autophagy from a spatiotemporal perspective.In par-ticular,we focused on three important membrane remodeling processes in autophagy,lipid transfer for phagophore elongation,membrane scission for phago-phore closure,and autophagosome-lysosome mem-brane fusion.We discussed the significance of the discoveries in this field and possible avenues to follow for future studies.Finally,we summarized the mem-brane-associated biochemical techniques and assays used to study membrane properties,with a discussion of their applications in autophagy.