Degeneration Versus Development:Hunting-Out the D-Unit of Huntington's Disease

• 作者: Shengyi Lu Boxun Lu
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Research Highlights
• 页码范围: 757-760
• 页数: 4页
• 语种: 英文

摘要

Huntington's disease(HD)is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion exceeding a threshold length(＞35 repeats)in exon 1 of the huntingtin gene(HTT)[1].The age at onset is typically 40-50 years,except for a very low percentage(approximately 6％)of juvenile-onset HD patients carrying 75 or more CAG repeats;longer CAG repeats predict an earlier onset[1].The clinical features of HD vary among individuals but are typically characterized by progressive motor dysfunction,cognitive disorder,and psychiatric disturbance[1].HD patients are usually healthy before the onset,showing no diagnosable symptoms[1].