Dear Editor,We present a case of uveal melanoma during pregnancy with a rapid tumor growth rate and unusual muscle invasion.Uveal melanoma,the most common intraocular primary malignancy in adults,is uncommon during pregnancy.Due to tremendous physiological changes during this period,especially elevated levels of estrogen and progesterone,the clinical features and outcomes may be different.This study was approved by the Institutional Ethical Committee of the Eye and ENT Hospital of Fudan University,and we confirmed that all written consents were obtained from the patient.