Let g be a (twisted or untwisted) affine Kac-Moody algebra,and μ be a diagram automorphism of g.In this paper,we give ah explicit realization for the universal central extension (g)[μ]of the twisted loop algebra of g with respect to μ,which provides a Moody-Rao-Yokonuma presentation for the algebra (g)[μ]when μ is non-transitive,and the presentation is indeed related to the quantization of twisted toroidal Lie algebras.