Breakthrough in Structural and Functional Dissection of the Hypothalamo-Neurohypophysial System

• 作者: Ying Wang Huamin Xu Xia Zhang
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Research Highlights
• 页码范围: 1087-1089
• 页数: 3页
• 语种: 英文

摘要

The projections from hypothalamic magnocellular neu-roendocrine cells(MNCs)to the posterior pituitary(PPi)are traditionally defined as the hypothalamo-neurohy-pophysial system(HNS),which releases oxytocin(OXT)and arginine vasopressin(AVP)into the blood stream to regulate peripheral function[1].Recently,accumulating evidence has confirmed that OXT and AVP are not only involved in peripheral regulation[2],but also contribute to various central actions[3,4],such as memory and social and stress-related behaviors[5].However,peripherally released OXT and AVP rarely cross the blood-brain barrier and return to the central nervous system.So,whether and how they exert central effects remain to be elucidated.