Fibronectin type Ⅲ domain-containing 5 in cardiovascular and metabolic diseases:a promising biomarker and therapeutic target

• 作者: Xin Zhang Can Hu Hai-ming Wu Zhen-guo Ma Qi-zhu Tang
• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2021,（9）
• 所属期刊栏目: Review Article
• 页码范围: 1390-1400
• 页数: 11页
• 语种: 英文

摘要

Cardiovascular and metabolic diseases are the leading causes of death and disability worldwide and impose a tremendous socioeconomic burden on individuals as well as the healthcare system.Fibronectin type Ⅲ domain-containing 5 (FNDC5) is a widely distributed transmembrane glycoprotein that can be proteolytically cleaved and secreted as irisin to regulate glycolipid metabolism and cardiovascular homeostasis.In this review,we present the current knowledge on the predictive and therapeutic role of FNDC5 in a variety of cardiovascular and metabolic diseases,such as hypertension,atherosclerosis,ischemic heart disease,arrhythmia,metabolic cardiomyopathy,cardiac remodeling,heart failure,diabetes mellitus,and obesity.