Dear Editor,
Targeted protein degradation (TPD) represents a promising research field that has quickly attracted attention and efforts from both academia and pharmaceutical industry.TPD technology uses small molecules to induce the degradation of target proteins by harnessing the ubiquitin-proteasome system.PROTAC (PROteo-lysis Targeting Chimeras)1-3 and MG (Molecular Glue)4,5 are two major modes of TPD.PROTACs comprise three parts,including a ligand for binding a target protein,another ligand for recruiting an E3 ligase,and a linker,which helps anchoring the target protein to the E3 ubiquitin ligase,to promote its ubiquitination and subsequent proteasomal degradation.Similar to PROTACs,MGs can also cause ubiquitination and degradation of a target protein.