One Stone Two Birds—Enantioselective Bimetallic Catalysis for α-Amino Acid Derivatives with an Allene Unit

• 作者: Junzhe Xiao Haibo Xu Xiaohong Huo Wanbin Zhang Shengming Ma
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Comprehensive Reports
• 页码范围: 1958-1964
• 页数: 7页
• 语种: 英文
• DOI: 10.1002/cjoc.202100002

摘要

Main observation and conclusion A highly enantioselective 2,3-allenylation of acyclic and cyclic α-imino carboxylates via a synergistic bimetallic Pd/Cu catalysis with the same commercially available (R,Rp)-iPr-FOXAP (also as Phosferrox,(R,R)-[2-(4'-i-propyloxazolin-2'-yl)ferrocenyl]diphenyl phosphine)ligand for both metals affording optically active 2,3-butadienyl α-amino acid derivatives in high to excellent yields with excellent en-antioselectivities has been developed.