2-D/2-D heterostructured biomimetic enzyme by interracial assembling Mn3(PO4)2 and MXene as a flexible platform for real-time sensitive sensing cell superoxide

• 作者: Shen Fei Zhao Fang Xin Hu Zhuan Zhuan Shi Jing Jing Fu Yue Chen Fang Yin Dai Chun Xian Guo Chang Ming Li
• 来源期刊: 纳米研究（英文版）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Review Articles
• 页码范围: 879-886
• 页数: 8页
• 语种: 英文

摘要

It is critical for fabricating flexible biosensors with both high sensitivity and good selectivity to realize real-time monitoring superoxide anion (O2·-),a specific reactive oxygen species that plays critical roles in various biological processes.This work delicately designs a Mn3(PO4)2/MlXene heterostructured biomimetic enzyme by assembling two-dimensional (2-D) Mn3(PO4)2 nanosheets with biomimetic activity and 2-D MXene nanosheets with high conductivity and abundant functional groups.The 2-D nature of the two components with strong interfacial interaction synergistically enables the heterostructure an excellent flexibility with retained 100％of the response when to reach a bending angle up to 180°,and 96％ of the response after 100 bending/relaxing cycles.It is found that the surface charge state of the heterostructure promotes the adsorption of O2·-,while the high-energy active site improves electrochemical oxidation of O2·-.The Mn3(PO4)2/MlXene as a sensing platform towards O2·-achieves a high sensitivity of 64.93 μA·μM-1·cm-2,a wide detection range of 5.75 nM to 25.93 μM,and a low detection limit of 1.63 nM.Finally,the flexible heterostructured sensing platform realizes real-time monitoring of O2·-in live cell assays,offering a promising flexible biosensor towards exploring various biological processes.