Low-dose testosterone replacement therapy and electrically evoked resistance training enhance muscle quality after spinal cord injury

• 作者: Ashraf S.Gorgey Raymond E.Lai
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Perspectives
• 页码范围: 1544-1545
• 页数: 2页
• 语种: 英文

摘要

The current perspective is aimed to highlight the significance of adding low-dose testosterone replacement therapy (TRT) to electrically evoked resistance training (RT). Evoked RT is primarily designed to load the paralyzed lower extremity muscles to elicit muscle hypertrophy in persons with spinal cord injury (SCI) (Ryan et al., 2013; Gorgey et al., 2019). The rationale was based on previous work that indicated that high-dose TRT is likely to enhance muscle quality, increase muscle cross-sectional area, and attenuate trabecular bone loss in a rodent model of SCI (Yarrow et al., 2014). However, high-dose TRT may lead to negative medical consequences including the increased risk for blood clots and enlargement of the prostate gland in humans with SCI (Yarrow et al., 2014). As such a complementary approach of adding low-dose TRT to loading exercise may reciprocate the negative effects of SCI on body composition and cardio-metabolic profiles.