Disordered structure and flexible roles: using the prion protein N1 fragment for neuroprotective and regenerative therapy

• 作者: Behnam Mohammadi Hermann Clemens Altmeppen Markus Glatzel
• 来源期刊: 中国神经再生研究（英文版）
• 年，卷（期）: 2021,（7）
• 所属期刊栏目: Perspectives
• 页码范围: 1431-1432
• 页数: 2页
• 语种: 英文

摘要

The cellular prion protein (PrPC) is a truly remarkable cell surface glycoprotein. With (i) its broad expression pattern and (ii) particularly high levels in the nervous system, (iii) its critical involvement in fatal neurodegenerative diseases affecting different mammalian species, (iv) its structurally diverging bipartite buildup, (v) its high degree of evolutionary conservation and (vi) a variety of –at least suggested– functions despite (vii) a surprising lack of major phenotypic deficits when absent (as in respective knock-out animals), PrPC has raised considerable research interest over the last four decades.