H2A.Z contributes to trithorax activity at the AGAMOUS locus

• 作者: Un-Sa Lee Tomasz Bieluszewski Jun Xiao Ayako Yamaguchi Doris Wagner
• 来源期刊: 分子植物（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Correspondences
• 页码范围: 207-210
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, In multicellular eukaryotes,Polycomb repression heritably si-lences gene expression programs not needed or detrimental for a given developmental stage or tissue(Schuettengruber et al.,2017).During cell fate reprogramming,Polycomb silencing can be overcome by the combined activity of multiple Trithorax group(TrxG)proteins(Wu et al.,2012;Liang et al.,2015;Schuettengruber et al.,2017).TrxG proteins are genetically defined as suppressors of homeotic defects caused by loss of Polycomb function and have diverse enzymatic activities(Schuettengruber et al.,2017).We used a genetic enhancer screen to identify candidate TrxG proteins and uncovered TrxG activity for components of the SWR1 chromatin remodeling complex,which deposits the histone variant H2A.Z(Deal et al.,2007;March-Diaz et al.,2008).