Engineered Vasculature for Organ-on-a-Chip Systems

• 作者: Abdellah Aazmi Hongzhao Zhou Yuting Li Mengfei Yu Xiaobin Xu Yutong Wu Liang Ma Bin Zhang Huayong Yang
• 来源期刊: 工程（英文）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Bio-Manufacturing—Review
• 页码范围: 131-147
• 页数: 17页
• 语种: 英文

摘要

Organ-on-a-chip technology,a promising three-dimensional(3D)dynamic culture method,ensures accu-rate and efficient cell culture and has great potential for replacing animal models in preclinical testing.The circulatory system,the most abundant organ in the human body,plays a crucial role in oxygen exchange and mass transfer,which is the determining factor for the survival of tissues and organs.Thus,it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissue and organ microenvironments and physiological functions.This review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology,which offers even better possibilities of dupli-cating physiology and disease characteristics.In addition,we review the different steps of a vascularized organ-on-a-chip fabrication process,including structure fabrication and tissue construction using differ-ent biofabrication strategies.Finally,we outline the applicability of this technology in the fascinating and fast-developing field of organ and tumor culture.