TMED9-SEC12,an important "contact" for autophagy

• 作者: Claudia Puri David C.Rubinsztein
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 111-112
• 页数: 2页
• 语种: 英文

摘要

Autophagosome biogenesis occurs via a complex mechanism that involves membranes from different subcellular compart-ments.Here,we review an elegant study from Li et al.describing a new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that leads to the formation of COPⅡ-coated vesicles essential for the formation of the autop-hagosome,and attempt to reconcile their findings with our studies proposing that the recycling endosome is a core platform for autophagosome biogenesis.