New refractory high-entropy alloys, CrHfNbTaTi and CrHfMoTaTi, derived from the well-known HfNbTaTiZr alloy through prin-cipal element substitution were prepared using vacuum arc melting. The phase components, microstructures, and compressive properties of the alloys in the as-cast state were investigated. Results showed that both alloys were composed of BCC and cubic Laves phases. In terms of mech-anical properties, the yield strength increased remarkably from 926 MPa for HfNbTaTiZr to 1258 MPa for CrHfNbTaTi, whereas a promising plastic strain of around 15.0% was retained in CrHfNbTaTi. The morphology and composition of the network-shaped interdendritic regions were closely related to the improved mechanical properties due to elemental substitution. Dendrites were surrounded by an incompact inter-dendritic shell after Mo incorporation, which deteriorated yield strength and accelerated brittleness.