Comparison of One and Two Fractional Irradiation by X-rays on Fibroblasts

• 作者: WangJufang WeyratherWilma
• 来源期刊: 近代物理研究所和兰州重离子加速器实验室年报：英文版
• 学科: 生物学
• 关键词: 部分放射性 X-射线 纤维原细胞 末期分化模式 细胞生态学
• 年，卷（期）: 2003,（1）
• 页码范围: 81
• 页数: 1页
• 分类号: Q24

摘要

In order to investigate the fractional effect, normal human fibroblasts GM5758 were irradiated with oneand two fractional X-rays. After irradiation, cell survival was performed by standard methods. Cell terminal differentiation pattern was determined as mitotic fibroblasts (MF) Ⅰ, Ⅱ and Ⅲ, post mitotic fibroblasts (PMF) Ⅳ, Ⅴ and Ⅵ, according to cellular morphology, as described by C. Fournier. As show in Fig.l, the survival fraction of two-fraction irradiation is higher than that of one-fraction irradiation. This result suggests that sub-lethal damage induced by radiation can be repaired efficiently for fractional irradiation. As for differentiation