With the help of a continuation theorem based on Gaines and Mawhin's coincidence degree, easily verifiable criteria are established for the global existence of positive periodic solutions of a differential-integral predator-prey system with infinite delay dN1(t)/dt=N1(t)[b1(t)-a1(t)∫(-∞,t)K1(t-u)N1(u)du-α(t)∫(-∞,t)K2(t-u)N2(u)/(1+mN1(u))du,dN2(t)/dt=N2(t)[-b2(t)+a2(t)∫(-∞,t)K3(t-u)N1(u)/(1+mN1(u))du] where N1(t),N2(t)satisfy N1(t)=Ф1(t),N2(t)=Ф2(t),Фi∈BC((-∞,0],R+),Фi(0)>0,i=1,2∫(0,+∞)Ki(s)ds=1,i=1,2,3.