Synthesis and Characterization of Chitosan-Polyvinyl Alcohol Blended with Cloisite 30B for Controlled Release of the Anticancer Drug Curcumin

• 作者: Ashok Kumar Nayak Birendra Kumar Binhani P. L. Nayak Umesh Kumar Parida
• 来源期刊: 生物材料与纳米技术(英文)
• 学科: 医学
• 关键词: CHITOSAN PVA C 30B GLUTARALDEHYDE CURCUMIN DRUG Delivery
• 年，卷（期）: swclynmjsyw_2011,（4）
• 页码范围: 414-425
• 页数: 12页
• 分类号: R73

摘要

In the present research program, polymer nanocomposites have been used as the drug carrier for delivery systems of anticancer drug. Chitosan (Cs) and Polyvinyl Alcohol (PVA) with different ratios were blended with different wt% of Cloisite 30B solution by solvent casting method. Glutaraldehyde with different wt% was added to the blended solution as a crosslinking agent. Cloisite 30B was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Curcumin with different concentrations were loaded with CS-PVA/ C 30B nanocomposites for studying the in-vitro drug delivery systems. Morphology and structure characterization of nanocomposites were investigated by fourier transmission infra red spectroscopy (FTIR), scanning electron microscope (SEM), tensile strength and water uptake capacity. The drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.