Transforming growth factor-β and smooth muscle differentiation

• 作者: Shi-You Chen Xia Guo
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: TRANSFORMING growth factor β SMAD SMOOTH MUSCLE cell Differentiation CARDIOVASCULAR DISEASES
• 年，卷（期）: 2012,（3）
• 页码范围: 41-52
• 页数: 12页
• 分类号: R363

摘要

Transforming growth factor(TGF)-β family members are multifunctional cytokines regulating diverse cel- lular functions such as growth,adhesion,migration, apoptosis,and differentiation.TGF-βs elicit their effects via specific typeⅠand typeⅡserine/threonine kinase receptors and intracellular Smad transcription factors. Knockout mouse models for the different components of the TGF-β signaling pathway have revealed their critical roles in smooth muscle cell(SMC)differentia- tion.Genetic studies in humans have linked mutations in these signaling components to specific cardiovascular disorders such as aorta aneurysm and congenital heart diseases due to SMC defects.In this review,the current understanding of TGF-β function in SMC differentiation is highlighted,and the role of TGF-βsignaling in SMC- related diseases is discussed.