Growth Hormone Prevents the Memory Deficit Caused by Oxidative Stress in Early Neurodegenerative Stage in Rats

• 作者: Adrian Sandoval-Montiel Alejandro Zentella-Dehesa Diana Verónica Castillo-Padilla Gabino Borgornio-Pérez José Luis Ventura Gallegos Selva Rivas-Arancibia
• 来源期刊: 神经系统科学与医药(英文)
• 学科: 医学
• 关键词: Oxidative Stress GROWTH Hormone Insulin GROWTH Factor Ozone Serine-Threonine Protein Kinase Water MAZE Passive AVOIDANCE
• 年，卷（期）: 2012,（3）
• 页码范围: 287-293
• 页数: 7页
• 分类号: R73

摘要

Oxidative stress has been involved in neurodegenerative diseases. The growth hormone (GH) counteracts the levels of reactive oxygen species. Previously, we showed that the prolonged exposure to ozone causes oxidative stress in the hippocampus and memory deficits. In this work, we analyzed the effects of the growth hormone on the memory deficit generated by ozone exposure, growth hormone effects on the Insulin-like growth factor I (IGF-I), and the serinethreonine protein kinase (Akt) activation in the dentate gyrus. Our results show that GH prevents memory deficits in early stages of the neurodegenerative process.