Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

• 作者: Mytych Jennifer Wnuk Maciej
• 来源期刊: 生物材料与纳米技术(英文)
• 学科: 医学
• 关键词: Nanoparticles NANOTOXICOLOGY GENOTOXICITY Cytotoxicity EPIGENETICS
• 年，卷（期）: 2013,（1）
• 页码范围: 53-63
• 页数: 11页
• 分类号: R73

摘要

Nanoparticles are considered as powerful tools in nanotechnological applications. Due to their unique physicochemical properties, their interactions with different biological systems have been shown. Nanomaterials have been successfully used as coating materials or treatment and diagnosis tools. Nevertheless, toxic effects of nanoparticles in vitro and in vivo have also been reported. Here, we summarize the current state of knowledge on exposure routes, cellular uptake and toxicological activities of the commonly used nanoparticles. In this context, we discuss the mechanisms of toxicity of nanoparticles involving perturbation of redox milieu homeostasis and cellular signaling pathways.