Synthesis, Characterization, Crystal Studies of (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl) Acrylaldehyde

• 作者: J. Seetharamappa Veerendra Kumar A. Kalalbandi
• 来源期刊: 晶体结构理论与应用(英文)
• 学科: 化学
• 关键词: Single CRYSTAL Structure X-Ray Diffraction Intermediate of FLUVASTATIN INDOLES
• 年，卷（期）: 2013,（4）
• 页码范围: 148-154
• 页数: 7页
• 分类号: O6

摘要

We have synthesized and developed single crystals of the title compound (E)-3-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl) acrylaldehyde, which is a key intermediate of anti-cholesterol fluvastatin drug. It crystallized under orthorhombic system with a space group Pna21. The dihedral angle between the indole mean plane and 4-F-phenyl ring was observed to be 111.5 (3)° in the title molecule. Further, strong hydrogen bonds were not found in the crystal structure.