intravitreal triamcinolone acetonide 的安全: 在兔子的 electrophysiologic 和组织病理学说的学习

• 作者: Amal Ahmad El-Gohary Ghada Ghanem El-Hossary Laila Hassan M.El-Shazly
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: TRIAMCINOLONE ACETONIDE INTRAVITREAL INJECTION ELECTRORETINOGRAM
• 年，卷（期）: 2013,（6）
• 页码范围: 790-795
• 页数: 6页
• 分类号: R774.1

摘要

AIM:To evaluate the retinal safety of various doses of intravitreal triamcinolone acetonide(TA)in rabbits.METHODS:Thirty New Zealand albino rabbits were divided into five groups(six animals each).In group 1(control group),each animal received a single intravitreal injection of 0.1 mL phosphate buffered saline.In groups2,3,4 and 5,each rabbit received a single intravitreal injection of 4,8,16 and 32mg of TA,respectively.Each dose was contained in 0.1 mL phosphate buffered saline.Clinical ocular examinations were performed before the injection and on the 1st,3rd,10th and 17th postinjection days.A standard dark adapted electroretinogram(ERG)was obtained before injection and on the 3rd,10th and 17th post-injection days.After17d,animals were sacrificed and their eyes prepared for pathological examination.RESULTS:By monitoring ERG as a functional index for the retina,intravitreal injection of 4mg TA showed no significant ERG changes.At doses of 8,16 and 32,hyper-abnormal responses in a-and b-waves of ERG were detected on the 3rd post-injection day.These changes gradually returned back to normal limits after17d.Histopathological examination of the retina of all animals showed no pathological changes.CONCLUSION:High doses of intravitreal TA seemed to have enhancing effects on the retinal function with gradual return to normal limits with no pathological changes detected in examined eyes.