Chronic Administration of the Resveratrol or N-PEP-12 Ameliorates the Endothelial Dysfunction in Aging Rats

• 作者: Celeste Santamaria-Juarez Elizabeth Monserrat-Hernández Fausto Atonal-Flores Gonzalo Flores Jorge Flores-Hernández José Gustavo López-López Josue Hernández-Cabrera Ma. De Jesús Gómez-Villalobos Rubén Antonio Vázquez-Roque
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: RESVERATROL N-PEP-12 AGING VASCULAR ENDOTHELIUM Blood Pressure
• 年，卷（期）: 2014,（1）
• 页码范围: 69-74
• 页数: 6页
• 分类号: R5

摘要

Here we investigated the effects of chronic treated with resveratrol, a polyphenol (3,4’,5-trihydroxystilbene) found in more than 70 plant species and food products such as red grapes, berries and peanuts, or N-PEP-12, a mix of peptides, on arteries in aging rats. Aging rats have shown endothelial dysfunction. Aged Sprague-Dawley rats (18 months old) were treated with resveratrol (20 mg/kg/day by gavage) or N-PEP-12 (60 mg/kg/day by gavage) for 10 weeks. 24 hours after the last administration of resveratrol or N-PEP-12, the animals were weighed and diastolic and systolic blood pressure was measured by tail-cuff plethysmography. Thoracic and abdominal aorta artery segments were obtained from resveratrol-, N-PEP-12-and vehicle-treated rats and were mounted in isometric tension for isolated vessels. We found that resveratrol and N-PEP-12 improved acetylcholine-induced relaxation in the old animals. These results suggest that chronic administration of resveratrol or N-PEP-12 may in part reduce endothelial dysfunction in the aging.