Synthesis of Fluorinated Heterobicyclic Nitrogen Systems Containing 1,2,4-Triazine Moiety as CDK2 Inhibition Agents

• 作者: Faisal Mohammed Aqlan Mohammed Saleh Tawfik Makki Reda Mohammdy Abdel-Rahman
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Synthesis Fluoroheterobicyclic NITROGEN CDK2 INHIBITION Anti-Tumor Activity
• 年，卷（期）: yjhxgjqkyw_2015,（3）
• 页码范围: 200-211
• 页数: 12页
• 分类号: O6

摘要

New fluorine substituted heterobicyclic nitrogen system as imidozolopyrimidines (2,3), pyrimido- 1,2,4-triazinones (4-7), 1,2,4-triazinyl-1,2,4-triazine (12-16), 1,2,4-triazinyl-1,2,4-triazinones (14-17) and substituted thiobarbituric acids (19-20), have been synthesized using the reaction of 3- amino-5,6-di (4'-fluorophenyl)-1,2,4-triazine (1) with α,β–bifunctional compounds. Structures of the title compounds were characterized by UV, IR, 1H/13C-NMR and mass spectrometric method. The studied compounds were tested for CDK2 inhibiting activity in DNA damage, as well as in vitro anti-tumor activity.