Current focus of stem cell application in retinal repair

• 作者: Maria L Alonso-Alonso Girish Kumar Srivastava
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: RETINA ADIPOSE derived mesenchymal STEMCELLS EMBRYONIC stem cells Induced PLURIPOTENT STEMCELLS Cell therapy
• 年，卷（期）: 2015,（3）
• 页码范围: 641-648
• 页数: 8页
• 分类号: R

摘要

The relevance of retinal diseases, both in society＇seconomy and in the quality of people＇s life who suffer withthem, has made stem cell therapy an interesting topic forresearch. Embryonic stem cells （ESCs）, induced pluripotentstem cells （iPSCs） and adipose derived mesenchymal stemcells （ADMSCs） are the focus in current endeavors as asource of different retinal cells, such as photoreceptorsand retinal pigment epithelial cells. The aim is to applythem for cell replacement as an option for treating retinaldiseases which so far are untreatable in their advancedstage. ESCs, despite the great potential for differentiation,have the dangerous risk of teratoma formation as wellas ethical issues, which must be resolved before startinga clinical trial. iPSCs, like ESCs, are able to differentiatein to several types of retinal cells. However, the processto get them for personalized cell therapy has a high costin terms of time and money. Researchers are working toresolve this since iPSCs seem to be a realistic option fortreating retinal diseases. ADMSCs have the advantagethat the procedures to obtain them are easier. Despiteadvancements in stem cell application, there are stillseveral challenges that need to be overcome beforetransferring the research results to clinical application.This paper reviews recent research achievements of theapplications of these three types of stem cells as well asclinical trials currently based on them.