Mesenchymal stem cells： A new diagnostic tool？

• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: MESENCHYMAL stem cells Biomarkers NEXT GENERATION SEQUENCING DIAGNOSTIC TOOL Tumorinitiatingcells
• 年，卷（期）: 2015,（5）
• 页码范围: 789-792
• 页数: 4页
• 分类号: R

摘要

Mesenchymal stem cells （MSCs） are progenitor cellscapable of self-renewal that can differentiate inmultiple tissues and, under specific and standardized culture conditions, expand in vitro with little phenotypicalterations. In recent years, preclinical andclinical studies have focused on MSC analysis andunderstanding the potential use of these cells as atherapy in a wide range of pathologies, and manyapplications have been tested. Clinical trials usingMSCs have been performed （e.g. , for cardiac events,stroke, multiple sclerosis, blood diseases, auto-immunedisorders, ischemia, and articular cartilage and bonepathologies）, and for many genetic diseases, thesecells are considered an important resource. Consideringof the biology of MSCs, these cells may also be usefultools for understanding the physiopathology of differentdiseases, and they can be used to develop specificbiomarkers for a broad range of diseases. In thiseditorial, we discuss the literature related to the use ofMSCs for diagnostic applications and we suggest newtechnologies to improve their employment.