Renal progenitors: Roles in kidney disease and regeneration

• 作者: Brooke E Chambers Rebecca A Wingert
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: Kidney RENAL PROGENITOR NEPHROGENESIS Development NEPHRON REGENERATION Zebrafish Parietal epithelial CELL Tubular PROGENITOR CELL
• 年，卷（期）: 2016,（11）
• 页码范围: 367-375
• 页数: 9页
• 分类号: R

摘要

Kidney disease is a devastating condition that affects millions of people worldwide, and its prevalence is predicted to significantly increase. The kidney is a complex organ encompassing many diverse cell types organized in a elaborate tissue architecture, making regeneration a challenging feat. In recent years, there has been a surge in the field of stem cell research to develop regenerative therapies for various organ systems. Here,we review some recent progressions in characterizing the role of renal progenitors in development, regeneration,and kidney disease in mammals. We also discuss how the zebrafish provides a unique experimental animal model that can provide a greater molecular and genetic understanding of renal progenitors, which may contribute to the development of potential regenerative therapies for human renal afflictions.