Synthesis and Characterization of Kalata B2 Cyclotide (GLPVCGETCFGGTCNTPGCSCTWPICTRD) on Wang Resin, as Solid Support

• 作者: Pillai V. N. Rajasekharan
• 来源期刊: 药物化学期刊(英文)
• 学科: 化学
• 关键词: UPLC LC/MS 1HNMR IR
• 年，卷（期）: ywhxqkyw,（2）
• 页码范围: 46-55
• 页数: 10页
• 分类号: O62

摘要

With the help of the solid phase peptide synthesizing method, we synthesized Kalata B2 cyclotide and the final product was purified by preparative HPLC. The sequence of Kalata B2 is GLPVCGETCFGGTCNTPGCSCTWPICTRD and its m/z M + H mass is 2955.53. It had been first isolated from <em>Oldenlandia affinis </em>plant leaves extract which belongs to Rubiaceae family. The synthesis of Kalata B2 has been characterized through UPLC/MS, LC/MS, CD, 1HNMR, and IR.