Thoracic Air Leak Syndrome: A Rare and Fatal Complication of Allogeneic Stem Cell Transplant

• 作者: Abdullah Sakkat Matthew Patel Shariq Haider
• 来源期刊: 临床医学病理报告(英文)
• 学科: 医学
• 关键词: THORACIC Air Leak SYNDROME PNEUMOMEDIASTINUM BRONCHIOLITIS OBLITERANS Graft Versus Host Disease Allogeneic Stem Cell Transplant
• 年，卷（期）: lcyxblbgyw_2020,（4）
• 页码范围: 81-86
• 页数: 6页
• 分类号: R65

摘要

Thoracic air leak syndrome (TALS) is a rare complication of allogeneic stem cell transplant (Allo-SCT) and is associated with a poor prognosis. We report a case of a 67-year-old male, after 20 months of Allo-SCT for acute myeloid leukemia, who presented with fever and acute worsening dyspnea on a background of a 4-month history of slowly progressive dyspnea. He was initially diagnosed with parainfluenza pneumonia and later developed TALS as a result of bronchiolitis obliterans (BO) caused by chronic graft-versus-host disease (cGVHD). Herein, we highlight the importance of early recognition and treatment of non-infectious pulmonary complications of Allo-SCT.