LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice

• 作者: Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu Cao Huiling Cao Guozhi Xiao
• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 416-428
• 页数: 13页
• 语种: 英文

摘要

INTRODUCTION In vertebrates, the skeleton is formed through intramembranous and endochondral ossification.1–2 The former forms the skull vault and part of the clavicle directly through condensation and differentiation of mesenchymal stem cells (MSCs) into osteopro-genitors, osteoblasts, and, terminally, osteocytes, while the latter forms the majority of skeletal elements, including all long bones and vertebrae.