Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory,and Dendritic Structure in Mice

• 作者: Han Wang Hong-Li Wang Ji-Tao Li Rui Liu Tian-Mei Si Xiao-Dong Wang Ya-Xin Sun Yun-Ai Su
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2020,（8）
• 所属期刊栏目: Original Articles
• 页码范围: 860-874
• 页数: 15页
• 语种: 英文

摘要

Chronic stress may disrupt the normal neurode-velopmental trajectory of the adolescent brain (especially the prefrontal cortex) and contribute to the pathophysiology of stress-related mental illnesses,but the underlying molecular mechanisms remain unclear.Here,we investigated how synaptic cell adhesion molecules (e.g.,nectin3)are involved in the effects of adolescent chronic stress on mouse medial prefrontal cortex (mPFC).Male C57BL/6N mice were subjected to chronic social instability stress from postnatal days 29 to 77.One week later,the mice exposed to chronic stress exhibited impaired social recognition and spatial working memory,simplified dendritic structure,and reduced spine density in the mPFC.Membrane localization of nectin3 was also altered,and was significantly correlated with behavioral performance.Furthermore,knocking down mPFC nectin3 expression by adeno-associated virus in adolescent mice reproduced the stress-induced changes in behavior and mPFC morphology.These results support the hypothesis that nectin3 is a potential mediator of the effects of adolescent chronic stress on prefrontal structural and functional abnormalities.