Mitochondrial replacement in macaque monkey offspring by first polar body transfer

• 作者: Zhanyang Wang Yuzhuo Li Xianfa Yang Yan Wang Yanhong Nie Yuting Xu Xiaotong Zhang Yong Lu Tikui Zhang Qiming Liu Naihe Jing Zhen Liu Qiang Sun
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 233-236
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, Mitochondrial DNA(mtDNA)mutations are maternally inherited to the offspring and mitochondrial replacement therapy(MRT)provides a promising approach for preventing mtDNA-related diseases.1,2 First polar body transfer(PB1T)has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.4 However,generation of primate offspring using PB1T has not been reported.Here,we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey(Macaca fascicularis),a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT.