An approach for the simulation and optimization of continuous catalyst-regenerative process of reforming isproposed in this paper. Compared to traditional method such as finite difference method, the orthogonal collocation method is less time-consuming and more accurate, which can meet the requirement of real-time optimization (RTO). In this paper, the equation-oriented method combined with the orthogonal collocation method and the finite difference method is adopted to build the RTO model for catalytic reforming regenerator. The orthogonal collocation method was adopted to discretize the differential equations and sequential quadratic programming (SQP) algorithm was used to solve the algebraic equations. The rate constants, active energy and reaction order were estimated, with the sum of relative errors between actual value and simulated value serving as optimization objective function. The model can quickly predict the fields of component concentration, temperature and pressure inside the regenerator under different conditions, as well as the real-time optimized conditions for industrial reforming regenerator.