cGAS-STING signaling and function in metabolism and kidney diseases

• 作者: Juli Bai Feng Liu
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（10）
• 所属期刊栏目: Reviews
• 页码范围: 728-738
• 页数: 11页
• 语种: 英文
• DOI: 10.1093/jmcb/mjab066

摘要

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway senses the presence of cytosolic DNA and,in turn,triggers downstream signaling to induce the expression of inflammatory and type Ⅰ interferon genes in immune cells.Whereas the innate immune function of the cGAS-STING pathway is well studied over the past years,emerging evidence suggests that this signaling pathway may have additional functions beyond innate immune surveillance.Consistent with this no-tion,dysregulation of the cGAS-STING signaling pathway in adipocytes,hepatocytes,and renal proximal tubule epithelial cells are associated with metabolic dysfunction,impaired energy homeostasis,and kidney diseases.In this review,we summarize cur-rent understanding of the cGAS-STING pathway in several metabolic diseases such as obesity,insulin resistance,alcoholic and nonalcoholic fatty liver diseases,as well as acute kidney injury and chronic kidney disease.We also review the interaction be-tween the cGAS-STING pathway and lipid metabolism.Lastly,we discuss potential mechanisms by which cGAS-STING signaling regulates metabolism and point toward future avenues of research targeting the cGAS-STING pathway as possible means to treat common metabolic disorders.