Therapeutic effects of dental pulp stem cells on vascular dementia in rat models

• 作者: Dan Yang Duo Wang Hui Yue Jin Fu Jin-Yue Li Mei-Yu Yu Wei Li Xue-Mei Zhang Yang Sun Ying-Lian Zhou Yuan-Jiao Ouyang Zhuo-Min Jiao
• 来源期刊: 中国神经再生研究（英文版）
• 学科: 医学
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Neurodegenerative Diseases and Neural Regeneration
• 页码范围: 1645-1651
• 页数: 7页
• 分类号: No.R456|R741|Q983+.8
• 语种: 英文

摘要

Dental pulp stem cells are a type of adult stem cells with strong proliferative ability and multi-differentiation potential. There are no studies on treatment of vascular dementia with dental pulp stem cells. In the present study, rat models of vascular dementia were established by two-vessel occlusion, and 30 days later, rats were injected with 2 × 107 dental pulp stem cells via the tail vein. At 70 days after vascular dementia induction, dental pulp stem cells had migrated to the brain tissue of rat vascular dementia models and differentiated into neuron-like cells. At the same time, doublecortin, neurofilament 200, and NeuN mRNA and protein expression levels in the brain tissue were increased, and glial fibrillary acidic protein mRNA and protein expression levels were decreased. Behavioral testing also revealed that dental pulp stem cell transplantation improved the cognitive function of rat vascular dementia models. These findings suggest that dental pulp stem cell transplantation is effective in treating vascular dementia possibly through a paracrine mechanism. The study was approved by the Animal Ethics Committee of Harbin Medical University (approval No. KY2017-132) in 2017.