This paper is concerned with the spreading speeds of time dependent partially degenerate reaction-diffusion systems with monostable nonlinearity.By using the principal Lyapunov exponent theory,the author first proves the existence,uniqueness and stability of spatially homogeneous entire positive solution for time dependent partially degenerate reaction-diffusion system.Then the author shows that such system has a finite spreading speed interval in any direction and there is a spreading speed for the partially degenerate system under certain conditions.The author also applies these results to a time dependent partially degenerate epidemic model.