A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state

• 作者: Zhiyuan Liu Qiumin Le Yanbo Lv Xi Chen Jian Cui Yiming Zhou Deqin Cheng Chaonan Ma Xiujuan Su Lei Xiao Ruyi Yang Jiayi Zhang Lan Ma Xing Liu
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: ARTICLES
• 页码范围: 139-156
• 页数: 18页
• 语种: 英文

摘要

Dopamine (DA) level inthe nucleus accumbens (NAc) is critical for reward and aversion encoding.DA released from the ventral mesencephalon (VM) DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons (D1-MSNs) in the NAc to enhance DA release and augment rewards.However,how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-averSion balance remains elusive.Here we report that the ventral pallidum (VP)projection of NAc D1-MSNs (D1NAc-VP) is inhibited by rewarding st muli and activated by averslVe stimuli.In contrast to the VM projection of D1-MSN (D1NAc-VM),activation ofD1 NAc-VP projection induces aversion,but not reward.D1NAc-VP MSNs are distinct from the D1NAc-VM MSNs,which exhibit conventional functions of D1-MSNs.Activation of D1NAc-VP projection stimulates VM GABAergic transmission,inhibits VM DAergic neurons,and reduces DA release into the NAc.Thus,D1NAc-VP and D1NAc-VM MSNs cooperatively control NAc dopamine balance and reward-aversion states.