Down Regulation of MyD88 in Macrophages Treated with Liposomes Composed of Phosphatidylserine

• 作者: Futoshi Kurai Issei Kazume Masaki Otsuka Rui Tada Yoichi Negishi Yuka Takasugi Yukihiko Aramaki
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: PHOSPHATIDYLSERINE LIPOSOME MYD88 TGF-Β MACROPHAGE
• 年，卷（期）: 2013,（2）
• 页码范围: 248-254
• 页数: 7页
• 分类号: R73

摘要

We have recently demonstrated that liposomes composed of phosphatidylserine (PS-liposomes) suppressed nitric oxide and inflammatory cytokine productions following LPS stimulation in macrophages. In this study, we examined the effect of PS-liposomes on expressions of TLR-4 and MyD88, which are essential for the signal transduction in LPS stimulation. Expression of MyD88 was suppressed when macrophages were treated with PS-liposomes, but not with liposomes of phosphatidylcholine. No change in TLR-4 expression was observed. MyD88 suppression was restored to the control levels when cells were pre-treated with anti-TGF-β antibody, suggesting that TGF-β plays an important role in down-regulation of MyD88 following PS-liposome treatment.