Pulmonary Complications as a Cause of Death after Renal Transplantation

• 作者: Daniela Petrova Diyan Genov Ognian Georgiev Ventsislava Pencheva
• 来源期刊: 内科学期刊(英文)
• 学科: 医学
• 关键词: FATAL OUTCOME RECIPIENT IMMUNOSUPPRESSION
• 年，卷（期）: 2014,（2）
• 页码范围: 41-46
• 页数: 6页
• 分类号: R73

摘要

Objectives: To analyse the risk factors for death as a result of pulmonary complications in kidney transplant patients. Material and Methods: 267 patients after renal transplantation were prospectively studied. The kidney recipients were followed for the development of pulmonary complications and their outcome for a period of 7 years. Different noninvasive and invasive diagnostic tests were used in cases suspected for lung disease. Results: Risk factors for death as a result of pulmonary complications are development of lung diseases in the first six months after operation (P < 0.05), and immunosuppressive regimens that include mycophenolate mofetil (HR: 3.216;95% CI: 1.067 - 5.577;P = 0.011). The factors associated with lower rate of fatal outcome are positive serology test for Cytomegalovirus of the recipient before transplantation (P = 0.034) and use of azathioprine (HR: 0.720;95% CI: 0.526 - 0.986;P = 0.04). Conclusions: The risk factors may be used to identify patients at increased risk for death due to the pulmonary complications. Strictly monitoring of higher-risk patients can reduce the morbidity and mortality after renal transplantation.